Stem Cell-Based Tissue-Engineered Laryngeal Replacement
نویسندگان
چکیده
منابع مشابه
Stem Cell‐Based Tissue‐Engineered Laryngeal Replacement
: Patients with laryngeal disorders may have severe morbidity relating to swallowing, vocalization, and respiratory function, for which conventional therapies are suboptimal. A tissue-engineered approach would aim to restore the vocal folds and maintain respiratory function while limiting the extent of scarring in the regenerated tissue. Under Good Laboratory Practice conditions, we decellulari...
متن کاملTissue Engineering and Regenerative Medicine Stem Cell-Based Tissue-Engineered Laryngeal Replacement
Patientswith laryngeal disordersmay have severemorbidity relating to swallowing, vocalization, and respiratory function, forwhich conventional therapies are suboptimal. A tissue-engineered approach would aim to restore the vocal folds and maintain respiratory function while limiting the extent of scarring in the regenerated tissue. Under Good Laboratory Practice conditions, we decellularized po...
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Tissue and cell transplantation are regarded as a popular procedure in clinical sciences, prospecting a new horizon for several incurable diseases. Along with its usefulness, many ethical concerns accompany this development. The ethical issue of organ transplant is unique to the source used which includes: living related, living unrelated, cadaveric, and xenotransplant. Obtaining organs has a s...
متن کاملTissue-Engineered Larynx: Future Applications in Laryngeal Cancer
PURPOSE OF REVIEW This article reviews the latest developments in tissue engineering for the larynx with a specific focus on the treatment of laryngeal cancer. RECENT FINDINGS Challenges in tissue engineering a total larynx can be divided into scaffold design, methods of re-mucosalization, and how to restore laryngeal function. The literature described a range of methods to deliver a laryngea...
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Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an array of anti-inflammatory and anti-fibrotic mediators, and very importantly activate resident precursors. These properties form the basis for the strategy of clinical application of cell-based therapeutics for infl...
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ژورنال
عنوان ژورنال: STEM CELLS Translational Medicine
سال: 2016
ISSN: 2157-6564
DOI: 10.5966/sctm.2016-0130